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Biophotonics Faculty Candidate Seminar: "Stimulated Raman Spectroscopic Imaging for Biology and Medicine" by Chi Zhang

Friday, December 8, 2017 11:00 AM to 12:00 PM
CREOL Room 103

Chi Zhang, Ph.D.
Photonics Center, Electrical & Computer Engineering, and Biomedical Engineering,
Boston University, Boston, MA.


Label-free imaging has important translational value since it circumvents the requirement of exogenous labeling molecules which are either inapplicable for living systems or strongly perturbative for biological functionality. However, most label-free imaging tools lack information at the molecular level. Raman spectroscopy, using molecular vibrations as contrasts, can image chemical compositions in biological systems with high specificity. Nevertheless, spontaneous Raman scattering is a weak process and requires long signal integration time, which is not applicable to study highly dynamic living samples. Recently developed imaging technologies based on coherent Raman scattering, especially the stimulated Raman scattering (SRS), have significantly improved the imaging speed. The SRS imaging allows high-speed quantitation of chemical compositions and tracking of spatial-temporal dynamics of metabolites in real time and in vivo. Such information granted new insights in cell metabolism and enabled discoveries of new markers for disease treatment. I will introduce some of the recent achievements in the field of SRS spectroscopy and microscopy, including the hyperspectral SRS imaging, a cytometry platform enabling high-throughput single particle analysis (up to 11,000 particles per second), and a high-speed volumetric imaging modality (using Bessel beams for excitation). Moreover, I will briefly cover some of the recent biomedical discoveries we made using SRS technologies, including the new metabolic markers for cancer and the reprogramed spatial-temporal dynamics of lipid metabolism in living cancer cells under stress conditions. The continuous advancement in label-free spectroscopic imaging and cytometry would create new tools for diagnosis and new treatment strategies for diseases.


Chi Zhang is a Postdoctoral Associate at Boston University Photonics Center. He earned his B.S. degree in Optoelectronics from Tianjin University in 2007. In 2009, he started his Ph.D. study at the University of Michigan, Department of Chemistry, and graduated in 2014. After graduation, he joined Dr. Ji-Xin Cheng lab at Purdue University Weldon School of Biomedical Engineering as a Postdoc Associate. He was also the director of the Purdue BME Confocal Microscopy Imaging Facility. He moved to Boston University Photonics Center together with Dr. Ji-Xin Cheng lab in July 2017. He is now a Postdoc Associate affiliated to both the BME and ECE departments. He dedicated his career to developing innovative optical imaging and spectroscopic technologies to enable early diagnosis and precision treatment of human diseases. Currently, he focuses on building novel imaging and cytometric tools based on stimulated Raman scattering (SRS) spectroscopy, and using these tools to enable new biomedical discoveries and treatment strategies for diseases, especially for cancer. His research leverages innovations in optics, electrical engineering, and chemistry to solve problems in biological and medical sciences. He has authored more than 40 peer-reviewed journal publications in his field.

For additional information:

Peter J. Delfyett


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