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"Cells as Bits: Biomedical Diagnostics Inspired by Wideband Data Multiplexing Techniques" by Bahram Jalali

Tuesday, October 8, 2013 11:00 AM to 12:00 PM

Bahram Jalali, UCLA

Abstract:

Telecommunication systems routinely generate, capture and analyze data at rates exceeding billions of bits per second.  Interestingly, the scale of the problem is similar to that of blood analysis. With approximately 1 billion cells per milliliter of blood, detection of a few abnormal cells in a blood sample translates into a “cell error rate” of 10-12, a value strangely similar to the bit error rate in telecommunication systems.

 Motivated by WDM and time-stretch dispersive Fourier transform technologies, a new type of bright-field imaging known as STEAM has demonstrated imaging of cells with record shutter speed and throughput leading to detection of rare breast cancer cells in blood with one-in-a-million sensitivity. A second technique called FIRE is a new approach to fluorescent imaging that is based on wireless communication techniques. FIRE has achieved real-time pixel readout rates one order of magnitude faster than the current gold standard in high-speed fluorescence imaging.

 Finally, a new physics-based signal transformation will be introduced and demonstrated. It enables a digitizer to capture signals that would otherwise be beyond its bandwidth and at the same time, it compresses the digital data volume. This method is inspired by operation of Fovea centralis in the human eye and by anamorphic transformation in visual arts. The so-called Anamorphic Spectrum Transformation makes it possible to (i) capture high-throughput random signals in real-time and (ii) to alleviate the storage and transmission bottlenecks associated with the resulting “big data”.

Biography:

Prof. Jalali is the Northrop-Grumman Endowed Chair in Optoelectronics and Professor of Electrical Engineering at UCLA, the Director of Department’s Physical and Wave Electronics, with joint appointments in Biomedical Engineering, California NanoSystems Institute (CNSI) and Department of Surgery at the UCLA School of Medicine. He received his Ph.D. in Applied Physics from Columbia University in 1989 and was with Bell Laboratories in Murray Hill, New Jersey until 2002 before joining UCLA. He is a Fellow of IEEE, the Optical Society of America (OSA), and the American Physical Society (APS). He is the recipient of the R.W. Wood Prize from Optical Society of America for the invention and demonstration of the first Silicon Laser, and the Aron Kressel Award of the IEEE Photonics Society, and the Distinguished Engineering Achievement Award from the Engineers Council. In 2005 he was elected into the Scientific American Top 50, and received the BrideGate 20 Award in 2001 for his entrepreneurial accomplishments. He has published over 300 journal and conference papers, and holds 11 patents. During 2001-2004, he was a consultant at Intel Corporation’s optical and wireless communication divisions.

For more information:

Dr. Sasan Fathpour

Assistant Professor of Optics

407-823-6961

 


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