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Dr. Kyu Young Han

Dr. Kyu Young Han

Assistant Professor of Optics & Photonics

Optical Nanoscopy







Kyu Young Han received his BS and PhD in Chemistry from Seoul National University, Korea in 2004 and 2010. During his PhD, he worked at Max Planck Institute for Biophysical Chemistry in Germany where he achieved ultimate resolution of optical microscopy using stimulated emission depletion (STED) and ground state depletion (GSD) microscopy, and developed affordable time-gated STED. Since 2011, he has been working as a postdoc researcher at the University of Illinois, focusing on designing new optical tools for biological applications such as studying DNA-protein interactions, RNA imaging in live-cells and revealing nuclear structure in mammalian cells. His patent on STED microscopy was commercialized by Leica Microsystems.


Awards & Honors

2016 UCF Faculty Travel Award

Recent Publications

Goun Je, Benjamin Croop, Sambuddha Basu, Jialei Tang, Kyu Young Han* and Yoon-Seong Kim*
"Endogenous a-SYN protein analysis on human brain tissues using single-molecule pull-down assay"
bioRxiv, doi: 10.1101/188169 (2017)
Jialei Tang, Y. Sun, S. Pang and K.Y. Han
"Spatially encoded fast single-molecule fluorescence spectroscopy with full field-of-view"
Sci. Rep., 7, 10945 (2017)
I. Masuda, T. Igarasgi, R.Sakaguchi, R. Nitharwl, R. Takase, K.Y. Han, B.J. Leslie, C. Liu, H. Gamper, T. Ha, S. Sanyal, and Y.M. Hou
"A genetically encoded fluorescent tRNA is active in live-cell protein synthesis "
Nucleic Acids Res. 45, 4081-4093
P. Heo, Y. Yang, K.Y. Han, B. Kong, J. Shin, Y. Jung, C. Jeong, J.H. Shin, Y.K. Shin, T. Ha, and D.H. Kweon
"A chemical controller of SNARE-driven membrane fusion that primes vesicles for Ca2+-triggered millisecond exocytosis"
J. Am. Chem. Soc. 138, 4512-4521
J. Kwon, J. Hwang, J. Park, G.R. Han, K.Y. Han*, S.K. Kim*
"RESOLFT nanoscopy with photoswitchable organic fluorophores"
Sci. Rep. 5, 17804 (2015)
J. Zhang, J. Fei, B.J. Leslie, K.Y. Han, T.E. Kuhlman, T. Ha
"Tandem Spinach array for mRNA imaging in living bacterial cells"
Sci. Rep. 5, 17295 (2015)
B. Hua, K.Y. Han, R. Zhou, H. Kim, X. Shi, S.C. Abeysirigunawardena, A. Jain, D. Singh, V. Aggarwal, S.A. Woodson & T. Ha
"An Improved surface passivation method for single-molecule studies"
Nature Methods 11, 1233-1236 (2014)
K.Y. Han, B.J. Leslie, J. Fei, J. Zhang & T. Ha
"Understanding the photophysics of the Spinach-DFHBI RNA aptamer-fluorogen complex to improve live cell RNA imaging"
J. Am. Chem. Soc. 135, 19033-19038 (2013)
G. Vicidomini*, G. Moneron*, K.Y. Han*, V. Westphal, H. Ta, M. Reuss, J. Engelhardt, C. Eggeling & S.W. Hell
"Sharper low-power STED nanoscopy by time gating"
Nature Methods 8, 571-573 (2011)
K.Y. Han, S.K. Kim, C. Eggeling & S.W. Hell
"Metastable dark states enable ground state depletion microscopy of nitrogen vacancy centers in diamond with diffraction-unlimited resolution"
Nano Lett. 10, 3199-3203 (2010)


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Optoelectronics & Integrated Photonics
Quantum Dots & Nanostructures
Imaging, Sensing & Display
Optical Design & Image Analysis
Biological & Medical Imaging
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Optical Sensing
Lasers in Medicine
Optical Signal Processing
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