Giving to CREOL CREOL, The College of Optics & Photonics

Seminar : “Toward opto-biology: Fluorescence nanoscopy, single molecule techniques and RNA imaging probes” by Kyu Young Han

Monday, June 1, 2015 11:00 AM to 12:00 PM
CREOL Room 102

Celebrating the International Year of Light 2015

Kyu Young Han1,2

1Howard Hughes Medical Institute, Urbana, Illinois, USA

2Department of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA


Fluorescence microscopy is one of the most powerful tools in biology because it allows studying dynamics of living systems non-invasively and imaging specifically labeled biomolecules with high sensitivity. In this talk, I will present diffraction unlimited fluorescence nanoscopy, using fundamental optical transitions of molecules, such as stimulated emission depletion (STED) microscopy and reversible saturable optical fluorescence transition (RESOLFT) microscopy, highlighting their development and applications to biology. I will then briefly discuss a new single molecule tool that enables us to explore biomolecular interactions at physiologically relevant concentrations and GFP-like RNA imaging probes focusing on how we can maximize their usage via optical methods.  


Kyu Young Han obtained his PhD in Physical Chemistry in 2010 from Seoul National University, Korea. During his PhD, he worked at Max Planck Institute for Biophysical Chemistry in Göttingen, Germany where he demonstrated the maximum resolution of STED microscopy, and developed time-gated STED and ground state depletion microscopy with guidance of Prof. Stefan Hell. Since 2011, he has been working as a postdoc researcher at the University of Illinois in Prof. Taekjip Ha’s lab, focusing on designing new optical tools for biological applications and engineering genetically encoded RNA imaging probes for live-cell imaging. His current areas of interest are next-generation super-resolution imaging and label-free single molecule imaging techniques for probing the underlying mechanisms of complex cellular processes. He has a patent on STED microscopy and it was commercialized by Leica in 2012.  

For additional information: 

Dr. Aristide Dogariu


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