Giving to CREOL CREOL, The College of Optics & Photonics
Dr. Kyu Young Han

Dr. Kyu Young Han

Assistant Professor of Optics & Photonics

Optical Nanoscopy







Kyu Young Han received his BS and PhD in Chemistry from Seoul National University, Korea in 2004 and 2010. During his PhD, he worked at Max Planck Institute for Biophysical Chemistry in Germany where he achieved ultimate resolution of optical microscopy using stimulated emission depletion (STED) and ground state depletion (GSD) microscopy, and developed affordable time-gated STED. Since 2011, he has been working as a postdoc researcher at the University of Illinois, focusing on designing new optical tools for biological applications such as studying DNA-protein interactions, RNA imaging in live-cells and revealing nuclear structure in mammalian cells. His patent on STED microscopy was commercialized by Leica Microsystems.


Awards & Honors

2016 UCF Faculty Travel Award

Recent Publications

KY Han & T Ha
"Measuring molecular mass with light"
Nature Photonics (News and Views), In press (July 2018)
J Kim J, KY Han KY, N Khanna, Ha T & AS Belmont
"Nuclear speckle fusion via long-range directional motion regulates the number and size of speckles"
Nat. Comm., under review [bioRxiv 347955]
Jialei Tang & KY Han
"Clear, extended field-of-view single-molecule imaging by highly inclined swept illumination"
Optica, under review [bioRxiv 311753 (2018)]
Ian Khaw*, Benjamin Croop*, Jialei Tang, A Möhl, U Fuchs, & KY Han
"Flat-field illumination for quantitative fluorescence imaging"
Opt. Express 26, 15276-15288
JC Lee, Y Ma, KY Han & T Ha
"Background-free STED nanoscopy by polarization switching"
Nature Methods, under review
B Hua, Y Wang, S Park, KY Han, D Singh, JH Kim, W Cheng and T Ha
"Single-molecule centroid localization algorithm improves the accuracy of fluorescence binding assays"
Biochemistry 57, 1572–1576
G Je, Benjamin Croop, S Basu, Jialei Tang, KY Han* and YS Kim*
"Endogenous alpha-synuclein protein analysis from human brain tissues using single-molecule pull-down assay"
Analytical Chemisty 89, 13044-13048
Jialei Tang, YY Sun, S Pang and KY Han
"Spatially encoded fast single-molecule fluorescence spectroscopy with full field-of-view"
Sci. Rep. 7, 10945
I Masuda, T Igarasgi, R Sakaguchi, R Nitharwl, R Takase, KY Han, BJ Leslie, C Liu, H Gamper, T Ha, S Sanyal, and YM Hou
"A genetically encoded fluorescent tRNA is active in live-cell protein synthesis "
Nucleic Acids Res., 45, 4081-4093
P. Heo, Y. Yang, K.Y. Han, B. Kong, J. Shin, Y. Jung, C. Jeong, J.H. Shin, Y.K. Shin, T. Ha, and D.H. Kweon
"A chemical controller of SNARE-driven membrane fusion that primes vesicles for Ca2+-triggered millisecond exocytosis"
J. Am. Chem. Soc. 138, 4512-4521


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Optoelectronics & Integrated Photonics
Quantum Dots & Nanostructures
Imaging, Sensing & Display
Optical Design & Image Analysis
Biological & Medical Imaging
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Optical Sensing
Lasers in Medicine
Optical Signal Processing
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