5.6 μm quantum cascade lasers based on the Al0.78In0.22As/In0.69Ga0.31As active region composition with the measured pulsed room temperature wall plug efficiency of 28.3% are reported. Injection efficiency for the upper laser level of 75% was measured for the design by testing devices with variable cavity lengths. A threshold current density of 1.7 kA/cm2 and a slope efficiency of 4.9 W/A were measured for uncoated 3.15 mm × 9 μm lasers. Threshold current density and slope efficiency dependence on temperature in the range from 288 K to 348 K for the structure can be described by characteristic temperatures T0 ~140 K and T1 ~710 K, respectively.